Mild cognitive impairment
Conditions
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) The inclusion criteria for MCI are based on the Diagnostic and Statistical Manual for Mental Disorders (DSM-5) of the American Psychiatric Association (APA) fifth edition in 2013:1) The chief complaint of memory impairment (confirmed by the patient or family, or observed by a specialist); 2) Objective examination (such as neuropsychological test) shows a certain cognitive change, or a decrease in performance in one or more cognitive areas compared to individuals of the same age and education level; 3) Other cognitive functions are relatively intact or slightly impaired; 4) The ability to engage in daily activities is not affected; 5) Not meeting the diagnostic criteria for dementia. (2) Age >=50 years (3) All participants have normal vision or corrected-to-normal vision (4) No language communication barriers, can cooperate with the completion of the questionnaire (5) Patients who voluntarily participated in this study and signed informed consent
Exclusion criteria
Exclusion criteria: (1) Diagnosed with Alzheimer's disease (AD) according to the National Institute of Aging-Alzheimer's Disease Association diagnostic criteria (2) Diagnosed with Parkinson's disease dementia (PDD) according to the diagnostic criteria of the International Parkinson's and Movement Disorders Society (3) Rapid cognitive decline occurring over weeks or months, usually as a result of prion disease, tumor, or metabolic disorder (4) Vascular dementia (VaD) caused by cerebrovascular disease and dementia caused by other causes (5) Except those suffering from anxiety, depression and mental illness, or those taking psychotropic drugs for a long time (6) Cases of use of anticholinergic drugs, as they are known to affect cognitive performance and eye movement (7) Visual acuity < 0.4, blurred vision, diplopia and visual obstruction or severe hearing loss, unable to complete the scale assessment (8) Clinical diagnostic interviews were conducted with subjects and their relatives to rule out dementia and exclude those with MoCA score =17 (9) Participants who refuse to take part in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average latency of cognitive tasks; | — |
Secondary
| Measure | Time frame |
|---|---|
| The accuracy of cognitive tasks;Fixation duration (fixation stability);Saccade deviation;Levels of oxygenated hemoglobin in the frontal temporal lobe of the cerebral cortex during CPAST; | — |
Countries
China
Contacts
Public ContactNi Guoxin
The First Affiliated Hospital of Xiamen University
Outcome results
None listed