Perioperative Neurocognitive Disorder.
Conditions
Interventions
Sponsors
Dongguan People's Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Have a full understanding of the purpose and significance of this trial, voluntarily participate in this clinical trial, and have signed the informed consent form; 2. American Society of Anesthesiologists (ASA) grade I-III; 3. Patients who undergo elective lower limb surgery and need to undergo combined spinal-epidural anesthesia; 4. Age 60 and above (including 60 years old), gender is not limited; 5. Preoperative MMSE score for illiterate > 17 points, 20 points for primary school >, and 24 points for middle school or above>; 6. No sedative drugs, antidepressants or other drugs that may interfere with the central nervous system in the past 2 years; 7. No history of central nervous system or psychiatric and psychological diseases.
Exclusion criteria
Exclusion criteria: 1. Presence of contraindications to neuraxial anesthesia; 2. Severe systemic diseases (such as malignant tumors) that may affect the level of PND biomarkers in cerebrospinal fluid; 3. Long-term use of psychotropic drugs, steroid drugs, hormones; 4. Patients with a history of cognitive dysfunction in the past, and central nervous system diseases such as multiple sclerosis and neuromyelitis optica.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum adiponectin ;Cerebrospinal fluid neurofilament light chain protein;Preoperative and postoperative MMSE scores; | — |
Countries
China
Contacts
Public ContactXiaohong Chen
Dongguan People's Hospital,
Outcome results
None listed