lung tumor
Conditions
Interventions
Esketamine group:Esketamine
Parecoxib sodium group:Parecoxib sodium
Esketamine combined with parecoxib sodium group:Esketamine combined with parecoxib sodium
control group:Normal saline
Sponsors
Yongchuan Hospital affiliated to Chongqing Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade grade I or II. 2. Age range between 50 and 80 years. 3. All patients met the indications for thoracic surgery, excluding patients with contraindications to general anesthesia, allergies to esketamine and parecoxib, and patients with previous chronic painful disease, chronic inflammatory disease.
Exclusion criteria
Exclusion criteria: 1. Allergic to the drug used. 2. A clear history of mental abnormalities and a long history of psychotropic medication, or a diagnosis of anxiety or depression. 3. Significant hepatic and renal insufficiency (blood transaminase and creatinine levels above the upper limit of normal). 4. Patients with a previous history of gastrointestinal bleeding. 5. Patients at serious risk of elevated intracranial pressure, such as intracranial aneurysms 6. Undercontrolled or untreated hypertension (resting systolic/ DBP over 180/ 100mmHg). 7. In a patient with hyperthyroidism (hyperthyroidism) without untreated or poor therapeutic efficacy. 8. Before surgery, the patient himself has serious complications, such as branch enlargement or tuberculosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of IL-6 and CRP; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score and dose and number of salvage medication;Changes in blood pressure and heart rate;Occurrence of adverse reactions;Development of complications; | — |
Countries
China
Contacts
Public ContactYan Dong; Li Jingnan
Yongchuan Hospital affiliated to Chongqing Medical University
Outcome results
None listed