Tourette syndrome
Conditions
Interventions
FC-group:Functional connectivity-guided rTMS targeting was used with 1 Hz stimulation administered twice daily (morning and afternoon) for two consecutive weeks. Each session involved 1,800 pulses at
T Group:Traditional Localization Group Stimulation Coordinates: The stimulation site is the left supplementary motor area (SMA), determined according to relevant literature as being located at 15% of
Sponsors
Hangzhou Normal University Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-40 years; 2. Diagnosis of Tourette syndrome (based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition [DSM-5]); 3. Wechsler Intelligence Scale score above 80; 4. Yale Global Tic Severity Scale (YGTSS) total motor + vocal tic score >= 20; 5. Minimal comorbidities, with no significant psychiatric symptoms; 6. At least six months of regular pharmacotherapy with unsatisfactory outcomes; 7. Able to accept TMS therapy, and willing to participate in the study treatment and follow-up.
Exclusion criteria
Exclusion criteria: 1. Participants with learning disabilities (e.g., intellectual disability, developmental delays, or speech delays). 2. Failure to meet the inclusion criteria specified by the clinical research protocol. 3. Presence of severe organic diseases affecting the cardiovascular, hepatic, renal, hematopoietic, or nervous systems, such as chronic nephritis, hepatitis, congenital heart disease, chorea, subacute encephalitis, etc. 4. Comorbidity with conduct disorder, pervasive developmental disorder, intellectual disability, mood disorders, or schizophrenia, among other mental health issues. 5. Inability to complete the full course of treatment, resulting in an inability to assess treatment efficacy or having incomplete data that affects the evaluation of efficacy or safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| YGTSS (Yale Global Tic Severity Scale);PUTS (Premonitory Urge for Tics Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| MEI related metrics; | — |
Countries
China
Contacts
Public ContactZang Yufeng
Hangzhou Normal University Affiliated Hospital
Outcome results
None listed