Postoperative cognitive dysfunction
Conditions
Interventions
Hyperoxia group:After the confirmation of endotracheal intubation, the subjects will be ventilated with FiO? = 1.0 and maintain ventilation with FiO? = 1.0 throughout all intraoperative mechanical ven
Physiological oxygenation group.:Immediately after intubation by the anesthesiologist, the FiO? will be reduced to 0.21. Subsequently, the anesthesiologist will increase or decrease the FiO? during pu
Sponsors
Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an)
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Aged 65 years or older; (2) Undergoing major non-cardiac surgeries under general anesthesia (with an expected postoperative hospital stay of more than 2 days); (3) Meeting the frailty criteria.
Exclusion criteria
Exclusion criteria: (1) Patients with disabling neuropsychiatric or neurological disorders (such as severe dementia, Alzheimer's disease, schizophrenia, severe depression); (2) Patients with delirium; (3) Patients who are unable to complete preoperative mental tests; (4) Use of home supplemental oxygen; (5) Preoperative supplemental oxygen to maintain an arterial oxygen saturation of 92%; (6) Right-to-left intracardiac shunts including atrial septal defect and ventricular septal defect combined with cor pulmonale; (7) Carotid artery stenosis defined as 50% stenosis of any carotid artery; (8) Currently using hemodialysis or peritoneal dialysis; (9) Patients who need to be transferred to the ICU after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma F2 - isoprostane and isofuran concentrations;Serum S100ß; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cerebral oxygen saturation;Mini - Mental State Examination;Confusion Assessment Method for the Intensive Care Unit;The Incidence of Postoperative Cognitive Dysfunction;The Incidence of Postoperative Delirium;Postoperative complications; | — |
Countries
China
Contacts
Public ContactJingjing Mao
Huai'an Hospital Affiliated to Yangzhou University (The Fifth People's Hospital of Huai'an)
Outcome results
None listed