Depression of respiration, Hypoxia
Conditions
Interventions
R Group:Remimazolam besylate for sedation
EP Group:Propofol combined with etomidate for sedation
Sponsors
Dazhou Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) Age> 65 years old, gender is not limited; (2) Clinical frailty scale (CFS) score>=5 points; (3) undergo digestive endoscopy for diagnosis and treatment; (4) American Society of Anesthesiologists (ASA) class II or III; (5) Understand and voluntarily participate in this study, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients undergoing complex endoscopic techniques for diagnosis or treatment; (2) Patients with severe respiratory pathologies (obstructive sleep apnea syndrome, acute respiratory tract infection, acute exacerbation of chronic obstructive pulmonary disease, uncontrolled asthma, oxygen saturation <90% in the inhaled state before examination, etc.) (3) Patients with hemodynamic instability (preoperative visit blood pressure = 180/110 mm Hg or systolic blood pressure <90mm Hg) (4) Those who are allergic to or contraindicated to benzodiazepines, opioids, propofol and etomidate; (5) Patients who were judged to have difficulties in airway management (modified Marhalanobis score grade IV.); (6) Those who have participated in clinical trials of other drugs in the past 3 months; (7) Other conditions that the investigator considers inappropriate to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of hypoxemia;Depression of respiration; | — |
Countries
China
Contacts
Public ContactLiang Wang
Dazhou Central Hospital
Outcome results
None listed