Resistant epilepsy comorbid with anxiety
Conditions
Interventions
Only one group, for their own before and after the control:Clobazam
Sponsors
Department of Neurology, Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age at enrollment between 16-65 years old (inclusive of boundary values); weight over 50kg;male or female; 2.Patients diagnosed with drug-resistant epilepsy according to the "Chinese Expert Consensus on Drug-resistant Epilepsy" published by the Epilepsy Committee of the Neurology Branch of the Chinese Medical Association in 2015, who visited the Epilepsy Clinic at the Affiliated Hospital of Zunyi Medical University between September 2024 and December 2025; 3.Clinically presenting with anxiety symptoms and meeting the diagnostic criteria for anxiety based on scale scores; 4. A score of 24 or higher on the Mini-Mental State Examination (MMSE); 5. No epileptic status in the 3 months prior to enrollment; 6.Signed informed consent and willing to cooperate with the experiment; 7. Not undergoing treatment for depression or anxiety; 8.Normal blood routine, liver and kidney function, electrolytes, and electrocardiogram (ECG) prior to enrollment
Exclusion criteria
Exclusion criteria: 1.Combined with severe organic diseases, such as cardiovascular and cerebrovascular diseases, etc.; 2.Those with mental disorders; 3. Alcohol dependent or drug abusers; 4.Pregnant or lactating women; 5.Those allergic to the study drugs; 6.Those with severe self-harm, suicidal behavior, and attempts; 7.Patients with abnormal liver and kidney function.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of seizures;Degree of improvement in anxiety.; | — |
Countries
China
Contacts
Public ContactZucai Xu
The Affiliated Hospital of Zunyi Medical University
Outcome results
None listed