Subclinical obesity
Conditions
Interventions
2.0mg group:Subclinically obese patients undergoing bidirectional endoscopy under unintubated sedation anesthesia were placed on a sedation regimen of oliceridine (test dose) combined with propofol (2
If the intraoperative reaction in the previous subject was a negative response, the dose of oliceridine administered to the next subject was decreased by one dose gradient until the subject had a posi
2.5mg group:Subclinically obese patients undergoing bidirectional endoscopy under unintubated sedation anesthesia were placed on a sedation regimen of oliceridine (test dose) combined with propofol (2
Sponsors
The Fifth People's Hospital of Huai'an
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1,Subjects clearly understand, voluntarily participate in the study, and sign an informed consent form by themselves;2, ASA class I-II;3,Aged 18 to 65 years; 4,BMI>=28 kg/?; 5,Elective bidirectional endoscopy.
Exclusion criteria
Exclusion criteria: 1,Presence of speech communication, vision, or hearing impairments;2, Presence of psychosomatic or neurological disorders;3, Presence of acute or severe bronchial asthma, Mallampati classification >3, severe difficult airways, and severe sleep apnea using a ventilator;4, Known or suspected gastrointestinal obstruction;5,Participation as a subject in a clinical trial of another drug within the past 3 months;6,Allergy to or contraindication to propofol, opioids, and their drug components;7,Treatment with sedative and hypnotic medications within the past 48 hours,as well as alcohol or drug abuse;8,Examination time more than 30 minutes;9,Participation in this trial is deemed inappropriate by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroscope placement reaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oliceridine dose;Mean arterial pressure at each time point;Time of examination;Bracketed jaw condition;Vasoactive drug use;Total propofol dose;Heart rate at each time point;Oxygen saturation at each time point;Time of awakening;Time of leaving the hospital;Mask pressurization;Use of antagonistic drugs;Perioperative hypotension;Perioperative bradycardia;Decreased perioperative oxygen saturation;Other perioperative adverse reactions; | — |
Countries
China
Contacts
Public ContactYongjiu Ji
The Fifth People's Hospital of Huai'an
Outcome results
None listed