paediatric diffuse low-grade glioma
Conditions
Interventions
Gold Standard:Clinical features + histological morphology + immunohistochemical staining + central nervous system NGS (DNA and/or RNA) panel detection
Index test:Genome-wide DNA methylation 935K microarray detection and cluster analysis.
Sponsors
The First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: 1.Regardless of gender, under the age of 40; 2.The pathological tissue morphology of the biopsy after surgery is consistent with diffuse low-grade glioma; 3.Able to provide sufficient samples (20 10 µm thick paraffin samples); 4.Complete clinical background information, including basic information of subjects (gender, age, etc.), clinical information, imaging data, HE electronic sections, etc. 5.Voluntarily participate in this diagnostic test and sign the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Patients who have received chemotherapy or radiotherapy or targeted drug therapy before surgery; 2.The morphology of the postoperative biopsy tissue showed localized glioma or diffuse high-grade glioma; 3.Samples whose case information is incomplete; 4.Sample collection and storage of samples that do not meet the requirements;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation diagnostic results;Sensitivity;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| The area under the AUC curve, AUC; | — |
Countries
China
Contacts
Public ContactXiaohong Yao
The First Affiliated Hospital of Army Medical University
Outcome results
None listed