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Effects of esmolol on stress and inflammatory response and incidence of postoperative nausea and vomiting in patients with sinusitis or nasal polyp during endoscopic sinus surgery

Effects of esmolol on blood pressure, heart rate and inflammatory response and incidence of postoperative nausea and vomiting in patients with sinusitis or nasal polyp during endoscopic sinus surgery

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400095027
Enrollment
Unknown
Registered
2024-12-31
Start date
2022-09-29
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sinusitis, nasal polyps

Interventions

Esmolol group:On the basis of control group , anesthesia induction increased the dose of esmolol by 0.5mg/kg, anesthesia maintenance increased esmolol by 30 µg/kg/min, and stopped pumping until the en
Control group:Conventional general anesthesia induction and maintenance: General anesthesia induction (intravenous injection of midazolam 0.05mg/kg, sufentanil 0.3 µg/kg, propofol 2mg/kg, cisatracuriu

Sponsors

Tengzhou Central People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with sinusitis or nasal polyps undergoing endoscopic surgery under general anesthesia, aged 20-60 years, ASA I-II grade, signed informed consent forms before surgery.

Exclusion criteria

Exclusion criteria: Exclude patients with cardiovascular, respiratory, neurological, and psychiatric disorders.

Design outcomes

Primary

MeasureTime frame
Blood pressure and heart rate values;Blood glucose levels;Expression level of blood inflammatory factors;Blood cortisol level;

Secondary

MeasureTime frame
Adverse reaction incidence rate;Intraoperative bleeding volume of the patients;Patient's postoperative recovery time;

Countries

China

Contacts

Public ContactZhang Mingyang

Tengzhou Central People's Hospital

zhangmingyang878@126.com+86 135 6118 5733

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 29, 2026