Postoperative fatigue syndrome
Conditions
Interventions
Dexmedetomidine Group:Before patients fall asleep, dexmedetomidine will be sprayed into the nasal cavity, 1 spray on each nostril and stayed for 30s, and then 1 spray on each nostril for a total of 4
Saline Group:Before patients fall asleep, normal saline will be sprayed into the nasal cavity, 1 spray on each nostril stayed for 30s, and then 1 spray on each nostril for a total of 4 sprays, and the
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Ages greater than or equal to 18 years old; 2. Scheduled for elective laparoscopic radical resection of colorectal cancer under general anesthesia; 3. ASA grades I-III.
Exclusion criteria
Exclusion criteria: 1. History of radiotherapy or chemotherapy for colorectal cancer; 2. Communication barriers or an inability to understand the scales involved in this study; 3. History of upper respiratory tract infection in the last 15 days; 4. Preoperative left ventricular ejection fraction <40%, second degree or greater atrioventricular block, pathological sinus syndrome, or preoperative heart rate less than 50 beats/min; 5. History of severe cardiovascular or cerebrovascular disease; 6. History of severe liver or kidney insufficiency; 7. Moderate to severe anemia or coagulopathy; 8. History of neurological, vascular, or musculoskeletal disorders; 9. Allergic to dexmedetomidine; 10. Patients with the preoperative Christensen score of 6 or more; 11. Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative fatigue syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration and severity of postoperative fatigue;Changes in fatigue scores;Sleep quality ;Postoperative pain scores;Time to first press of patient-controlled analgesia;Number of presses for patient-controlled analgesia;Number of patients received remedial analgesia;Total amount of postoperative analgesic drugs;Consumption of intraoperative anesthetic drugs;Intraoperative hemodynamics;The consumption of intraoperative vasoactive drugs;Inflammatory markers;Postoperative recovery quality;Time to first flatus and defecation;The incidence of adverse events;The degree of patients' satisfaction during hospitalization;Length of hospital stay;Time to extubation;Sedation scores after intervention;athens insomnia scale scores; | — |
Countries
China
Contacts
Public ContactSu Liu
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed