Pregnancy with chronic viral hepatitis B
Conditions
Interventions
Women of normal childbearing age group:None
Pregnant women with chronic hepatitis B group:None
Pregnant women without hepatitis B group:None
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Research group: Women; Between the ages of 20 and 40; HBsAg positive for >= 6 months; Any time point from 1 week of pregnancy to delivery is acceptable. (2) Negative control group: female; Between the ages of 20 and 40; HBsAg negative; Not pregnant. (3) Positive control group: female; Between the ages of 20 and 40; HBsAg negative; Any time point from 1 week of pregnancy to delivery is acceptable. All patients should have good compliance.
Exclusion criteria
Exclusion criteria: 1.Concomitant viral hepatitis A, C, E or other hepatotropic virus infection or AIDS; 2.Concomitant cirrhosis, liver cancer, or other chronic liver disease; 3.Patients with viral myocarditis, chronic kidney disease, ALI and other important organ diseases; 4.Accompanied by autoimmune hepatitis, autoimmune diseases, hypertension, diabetes, thyroid disease; 5.Multiple pregnancies; 6.Those who have complications in previous pregnancies; 7.Those who have had fetal or neonatal growth and development defects in previous pregnancies; 8.Previous or ongoing use of nephrotoxic drugs, glucocorticoids, cytotoxic drugs, or immunomodulators; 9.Failure to return to the hospital for regular follow-up visits as planned by the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MDSCs related indicators;Indicators of maternal immune status;Interaction of MDSCs with other immune cells;Gene expression profiling, pathway ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy comorbidities related indicators;Fetal health indicators; | — |
Countries
China
Contacts
Public ContactXingfei Pan
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed