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Study on optical effect and wound healing mechanism of retransplantation after laser remodeling of corneal stromal convex lens in vitro

Study on optical effect and wound healing mechanism of retransplantation after laser remodeling of corneal stromal convex lens in vitro

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094999
Enrollment
Unknown
Registered
2024-12-31
Start date
2025-02-01
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

keratoconus

Interventions

Group 1:The lens was removed without excimer cutting. The thickness of the lens was measured by OCT, the transmittal rate of the lens was measured by enzymoleter, and the lens was observed by optical
Group 2:The removed lens was cut 1:1 excimolecule according to the effective diopter. The thickness of the lens was measured by OCT, the transmittivity of the lens was measured by an enzyme spectromet
Group 3:The removed lens was cut 1:1.5 excimolecule according to the effective diopter. The thickness of the lens was measured by OCT, the transmittivity of the lens was measured by an enzyme spectrom
Group 4:The removed lens was cut 1:2 excimolecule according to the effective diopter. The thickness of the lens was measured by OCT, the transmittivity of the lens was measured by an enzyme spectromet

Sponsors

Jinan Mingshui Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
17 Years to 35 Years

Inclusion criteria

Inclusion criteria: 1.The patient had a desire to take the mirror and had a reasonable expectation of the surgical effect. 2.Age 17-35 years old; 3. The dioptric state was stable, and the annual increase of myopia dioptric number did not exceed 0.5D within two years. 4.Diopter: equivalent spherical lens degree -3.00D to -8.00D, column lens degree =1.00D; 5. Pupil diameter: open pupil =5cm, dark pupil =8cm; 6.Stop wearing soft contact lenses for at least 10 days, hard contact lenses for at least 1 month, and orthokeratology lenses for at least 3 months.

Exclusion criteria

Exclusion criteria: 1. The presence of keratoconus, glaucoma, cataract affecting vision, retinitis pigmentosa, retinal detachment, severely dry eyes, active eye inflammation or severe ocular adnexal diseases (eyelid defect or deformation); 2. Amblyopia; 3. Central corneal thickness (CCT)<460 µ M and residual corneal thickness (RCT) are less than 50% of preoperative corneal thickness; 4. Suffering from diabetes, immune and collagen diseases, scar constitution and other diseases that affect postoperative healing; 5. Suffering from mental illnesses such as anxiety or depression.

Design outcomes

Primary

MeasureTime frame
Corneal stromal lens thickness;Corneal stromal lens transmittance;

Secondary

MeasureTime frame
Corneal stromal lens water loss rate;Degree of corneal stromal lens expansion;

Countries

China

Contacts

Public ContactYu lin,Lei

Jinan Mingshui Eye Hospital

leiyulin642@126.com+86 178 5411 6868

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026