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Study on the protocol and related mechanism of combined pretreatment of GnRHa and letrozole to improve clinical outcomes in infertile patients with ovarian chocolate cysts before IVF

Study on the protocol and related mechanism of combined pretreatment of GnRHa and letrozole to improve clinical outcomes in infertile patients with ovarian chocolate cysts before IVF

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094991
Enrollment
Unknown
Registered
2024-12-31
Start date
2025-01-01
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endometriosis combined with infertility

Interventions

GnRHa and letrozole combination group:The IVF treatment plan for the GnRHa and letrozole combination pretreatment group in patients with polycystic ovary syndrome: injecting the first dose of long-act
On the 28th day after the second GnRHa injection, ultrasound and blood hormone tests were performed, and based on the results, gene recombinant FSH or gene recombinant FSH+HMG ovulation induction ther
Single use GnRHa group:The IVF treatment plan for patients with clever cysts treated with GnRHa alone: during pretreatment, GnRHa long-acting triptorelin (GnRHa) 3.75mg was used alone, without the add

Sponsors

The First Affiliated Hospital of Sun Yat-sen University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Select 110 IVF patients who failed in the first cycle of IVF (excluding male factors and without undergoing cystectomy); Body mass index (BMI)1.0ng/mL, AFC>5; Age<40 years old.

Exclusion criteria

Exclusion criteria: Received hormone therapy in the past 3 months; Suffering from infectious diseases or other serious systemic diseases (such as immune disease, coagulation dysfunction, serious cardiovascular disease, etc.; history of ovarian tumor, radiotherapy and chemotherapy); Smoking history; Repeated planting failures; Habitual miscarriage; Abnormal uterine diseases (intrauterine adhesions; uterine polyps; submucosal uterine fibroids); Uterine adenomyosis.

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy rate;

Countries

China

Contacts

Public ContactZengyan Wang

First Affiliated Hospital of Sun Yat sen University

wangzyan@mail.sysu.edu.cn+86 135 7020 2936

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026