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The effect and mechanism of peripheral nerve bundle electrical stimulation based on hand action decoding on hand function in stroke patients

The effect and mechanism of peripheral nerve bundle electrical stimulation based on hand action decoding on hand function in stroke patients

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094972
Enrollment
Unknown
Registered
2024-12-31
Start date
2025-01-01
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

About 80% of stroke patients will have sequelae such as limb dysfunction, and more than 60% of patients will be accompanied by upper limb motor dysfunction, especially hand dysfunction. It is mainly manifested as loss of hand motor function and inability to complete activities of daily living.

Interventions

Control group?:Muscle belly motor point stimulation
Experimental group ?:Motor decoding, nerve electrical stimulation, feedback, closed-loop motor rehabilitation training
Experimental group ?:Electrical stimulation of peripheral nerve bundles
Control group?:Traditional rehabilitation techniques

Sponsors

The First Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. hemorrhagic or ischemic stroke confirmed by imaging (computed tomography or magnetic resonance imaging); 2. age 30-80 years old; 3. unilateral hemisphere disease with unilateral limb paralysis; 4. within 1 year after stroke onset; 5. Clinically diagnosed arm and hand motor dysfunction (autonomic activity limitation); 6. The skin of both arms was intact without sensory disturbance; 7. no cognitive impairment (MMSE score: illiterate > 17; Primary school > 20 points, junior high school and above > 24 points); 8. Informed consent was obtained from patients or their families.

Exclusion criteria

Exclusion criteria: 1. diagnosed with any clinically significant or unstable medical illness; 2. implanted electronic device (pacemaker); 3. neuropsychiatric comorbidities other than stroke, such as schizophrenia, bipolar disorder, obsessive-compulsive disorder, or personality disorder, and major depressive disorder; 4. Skin injury, infection, hypoalgesia and intolerance at the stimulation site; 5. inability to follow treatment instructions due to severe cognitive and communication impairments; 6. No informed consent was obtained from patients or their families.

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer score of upper extremity;Modified ashworth scale;

Secondary

MeasureTime frame
Cortical activation level;Amplitude of electromyography;

Countries

China

Contacts

Public ContactYu Peng

The First Affiliated Hospital of Xi'an Jiaotong University

py7872@xjtufh.edu.cn+86 29 85323215

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026