Depression
Conditions
Interventions
Active TI stimulation treatment group-1:Participants are randomly assigned to receive 10 true stimuli for 30 minutes each time, the stimulation targets were: Fpz, Fp2
C5, TP7, the stimulation frequency was 20Hz envelope frequency, the current was 2mA, 2 weeks, 5 days a week, once a day, a total of 10 treatments
Active TI stimulation treatment group-2:Participants are randomly assigned to receive 10 true stimuli for 30 minutes each time, the stimulation targets were: Fpz, Fp2
C5, TP7, the stimulation frequency was 20Hz envelope frequency, the current was 15mA, 2 weeks, 5 days a week, once a day, a total of 10 treatments
Sham TI stimulation group:Participants are randomly assigned to receive 10 true stimuli for 30 minutes each time, the stimulation targets were: Fpz, Fp2
C5, TP7, the stimulation frequency was 20Hz envelope frequency, the current was 0mA, 2 weeks, 5 days a week, once a day, a total of 10 treatments
Sponsors
the First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) 16-65 years old, Han nationality; (2) Meet the diagnostic criteria for monophasic, non-psychotic MDD in the fourth Revision of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR34); (3) The total score of 17 items on the Hamilton Depression Scale (HDRS-17) was higher than 17 points at baseline; (4) acute attack; (5) No implants in the body (such as pacemakers, etc.); (6) There has been no loss of consciousness for more than 5 minutes since birth (except for sleeping pills and anesthesia for non-head surgery); (7) No craniocerebral injury or head surgery (especially craniotomy), no head wounds or skin diseases at present.
Exclusion criteria
Exclusion criteria: (1) Current or medical history of Axis I mental disorders (including manic or manic episodes, panic disorder, agoraphobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, psychosis, anorexia nervosa, bulimia nervosa, generalized anxiety disorder) and antisocial personality disorder, as assessed by MINI International Neuropsychiatric Interview (MINI) version 5.035; (2) Current or history of organic brain or neurological dysfunction; (3) Acute suicide risk, such as HDRS-17 suicide project score of 3 or 4; (4) cochlear implants, cardiac pacemakers and brain implants or metal; (5) Pregnant and lactating women; (6) Participate in concurrent clinical trials; (7) Refusing to sign the informed consent to participate in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The reduction ratio of HAMD-17 score at the end of the 2th week of treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-Rating Anxiety Scale; | — |
Countries
China
Contacts
Public ContactZhang Xiaochu
the First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed