Drug-resistant epilepsy
Conditions
Interventions
Microbiome therapy group:Probiotic intestinal flora transplantation
Control group:Oral treatment with antiepileptic drugs
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
12 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 12-60 years old, Han nationality; 2. Alone or in combination with 2 first-line antiepileptic drugs to reach the therapeutic dose, still have 2 (or more) seizures per month; 3. The type of seizure is not limited; 4. History of epilepsy greater than 1 year; 5. There was no change in the daily antiepileptic medication taken by the patient during the 3 weeks prior to the baseline period, and the participant agreed to keep the antiepileptic medication unchanged throughout the study; 6. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Use of antibiotics, probiotics or prebiotics within 4 weeks; 2. Bowel examination within 4 weeks; 3. Patients who have received physical treatment (electrical, magnetic, sound, light, etc.) for epilepsy within 4 weeks; 4. Have undergone intestinal surgery in the past; 5. Progressive brain disease or serious systemic disease other than epilepsy; 6. Severe depression, anxiety, obsessive-compulsive or other psychiatric diseases or drug or poison abuse; 7. Lactation or pregnancy; 8. Those who have sufficient experience and make a comprehensive judgment that the patient is not suitable for treatment after considering the patient's relevant condition.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Changes in the number of abnormal discharge activities such as spikes and spikes at baseline and at the end of treatment.; | — |
Primary
| Measure | Time frame |
|---|---|
| From the end of treatment to the end of follow-up, the frequency of seizures decreased by 100 points from baseline; | — |
Countries
China
Contacts
Public ContactZhongxin Li
The First Hospital of Hebei Medical University
Outcome results
None listed