knee osteoarthritis
Conditions
Interventions
Dexamethasone Group:Administer 0.15mg/kg dexamethasone via intravenous infusion pump before performing the block
Dexamethasone And Dexmedetomidine Group:Before proceeding with the block, 0.15mg/kg dexamethasone is administered via intravenous infusion pump. After induction of general anesthesia, the researchers
Placebo Saline Group:Before the block, a placebo saline solution is administered via an intravenous infusion pump. After induction of general anesthesia, the researchers administer a placebo saline so
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients who underwent unilateral TKA for osteoarthritis (OA), Planned ACB and IPACK blocks with intraoperative general anesthesia, were ASAI-III, had a body mass index of 18-30 kg/m^2, and were aged 18-80 years.
Exclusion criteria
Exclusion criteria: Impaired communication and understanding of language; peripheral neuropathy; known allergy to any study drug; patients who have taken analgesics and glucocorticoids in the past 3 months; or any contraindications to regional anesthesia, such as patient refusal, coagulopathy, or injection site infection; diabetes mellitus; severe liver or kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from block to the first request for analgesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain scores at rest ;Postoperative pain scores during movement ;Cumulative postoperative morphine consumption;postoperative sleep quality; | — |
Countries
China
Contacts
Public ContactHongfei Chen
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed