Laparoscopic nephrectomy
Conditions
Interventions
Liposomal Bupivacaine Group:Before induction, 10 ml of liposomal bupivacaine (133mg) mixed with 10 ml of normal saline is used to perform a quadratus lumborum block on the surgical side.
Bupivacaine Hydrochloride Group:Before induction, 20 ml of 0.375% bupivacaine hydrochloride is used to perform a quadratus lumborum block on the surgical side.
Sponsors
The Affiliated Hospital of Xuzhou Medical University.
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. 20 years old < age < 75 years old; 2. Body Mass Index (BMI): 20-30 kg/m^2; 3. American Society of Anesthesiologists (ASA) physical status classification: I-III; 4. Patients undergoing elective laparoscopic nephrectomy.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to regional block: coagulation disorders, infection at the puncture site, allergy to local anesthetics, etc.; 2. Long-term use of opioids or any analgesics for 3 months or more, history of chronic pain; 3. Allergy to medications used in the standardized anesthesia protocol; 4. Local or systemic infection; 5. Inability to use the PCA (Patient-Controlled Analgesia) system and pregnant patients; 6. History of neurological or psychiatric disorders, long-term use of sedative medications; 7. Inability to cooperate with the study for any reason: hearing impairment, language comprehension difficulties, not understanding the use of NRS (Numerical Rating Scale), refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total morphine equivalent consumption within 48 hours postoperatively.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative Quality of Recovery-15 (QoR-15) scores at 24 and 48 hours.;Numerical Rating Scale (NRS) pain scores ;The time of the first analgesic pump press postoperatively.;Incidence of rescue analgesia and dosage of rescue analgesic medication.;Incidence of postoperative nausea and vomiting.;Patient satisfaction;Sensory block level assessment 15 , 30 minutes after nerve block;Incidence of local anaesthetic poisoning;Surgical duration and intraoperative remifentanil consumption;Postoperative Athens Insomnia Scale (AIS) scores;The time of the first time getting out of bed after surgery.;PACU(Post-Anesthesia Care Unit) Stay Duration;Incidence of pruritus;Incidence of numbness in the blocked area;Other adverse reactions and the occurrence of complications; | — |
Countries
China
Contacts
Public ContactMengxing Jia
The Department of Anesthesiology at Xuzhou Medical University Affiliated Hospital
Outcome results
None listed