Diabetic retinopathy
Conditions
Interventions
Observation group:None
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with confirmed diabetes mellitus: meet internationally recognized diagnostic criteria for diabetes (such as those of the World Health Organization (WHO) or the American Diabetic Association (ADA)). Including people with type 1 diabetes and type 2 diabetes. 2. Age>=18 years. 3. The subjects can understand the purpose of the study, agree to complete the relevant examinations and collect biochemical, glycosylated hemoglobin eggs, C-reactive protein, erythrocyte sedimentation rate, renin + angiotensin + aldosterone data, ophthalmic imaging examinations including fundus photography, OCT results, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with other serious systemic diseases, such as advanced renal failure (eGFR <30 mL/min/1.73 m²), liver failure, heart failure and other serious systemic diseases, which may have a confounding effect on the research data. 2. Patients with other ophthalmic diseases: such as retinal vein occlusion, age-related macular degeneration, retinal detachment or other serious ophthalmic diseases that may interfere with the evaluation of diabetic retinopathy; 3. Pregnant or lactating women: Pregnant or lactating women are not suitable for inclusion in the study because physiological changes may affect the level of blood uric acid and metabolites. 4. Patients with acute inflammation or infection: Subjects have obvious acute inflammation or infection at screening, which may affect blood biochemical indicators. 5. Patients with severe mental illness or cognitive dysfunction: If the subject suffers from severe mental illness or cognitive dysfunction, it is difficult for the subject to cooperate with the study and follow-up work. 6. Subjects participating in other interventional clinical trials to avoid mutual interference between trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Classification of diabetic retinopathy;serum uric acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Macular retinal thickness;Indexes related to uric acid metabolism;Indexes related to plasma glucose;Indexes related to inflammation; | — |
Countries
China
Contacts
Public ContactLiu Kun
Shanghai General Hospital
Outcome results
None listed