postoperative atelectasis
Conditions
Interventions
Group P:Perform pulmonary protective ventilation and select the best PEEP guided by driving pressure
Group Cydn:Perform pulmonary protective ventilation and select the best PEEP guided by lung dynamic compliance
Group E:Perform pulmonary protective ventilation and select the best PEEP guided by EIT
Sponsors
The First Affiliated Hospital of Wannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Gender is not limited, age 18 to 45 years old, BMI >= 30/m^2, ASA grade I to III.
Exclusion criteria
Exclusion criteria: (1) Have a history of diseases or lung surgery that seriously affect thoracic or lung compliance, such as chicken breast, funnel chest, chest trauma, etc; (2) Have serious heart and lung diseases, cerebrovascular, liver, kidney, and blood system diseases, etc; (3) Severe hemodynamic fluctuations occur, making it difficult to correct with fluid replacement and vasoactive drugs; (4) Inability to maintain oxygen during surgery (SpO2 < 94% or PaO2 < 70 mmHg), or severe complications associated with mechanical ventilation (e.g. pneumothorax).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| globle inhomogeneity index, GI;center of ventilation, CoV;regional ventilation delay, RVD;region of interest,ROI;Changes in end-expiratory pulmonary impedance,?EELI; | — |
Secondary
| Measure | Time frame |
|---|---|
| PEEP value;PaO2/FiO2 ;SpO2 <92% at 30 min after extubation;Hemodynamic parameters: heart rate, mean arterial pressure;Respiratory mechanics parameters: peak pressure, plateau pressure, driving pressure, dynamic pulmonary compliance ;Intraoperative vasopressor drugs and dosages;Intraoperative fluid intake;Postoperative pulmonary complications and their severity; | — |
Countries
China
Contacts
Public ContactYongquan Chen; Yaqin Wang
The First Affiliated Hospital of Wannan Medical College
Outcome results
None listed