Effectiveness of central intermittent theta-burst stimulation associated with repetitive peripheral magnetic stimulation paired stimulation techniques on core muscle groups and postural control in patients with subacute stroke: a randomized controlled trial

Explore the effects of central iTBS combined with rPMS paired stimulation technique on core muscle groups and postural control in stroke patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400094934

Enrollment

Unknown

Registered

2024-12-30

Start date

2025-01-01

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

central-associated peripheral stimulation (CPS) group:central iTBS associated rPMS paired stimulation+conventional physical therapy

central-stimulation group:central iTBS associated sham rPMS paired stimulation+conventional physical therapy

control group: sham stimulation+conventional physical therapy

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Meet the diagnostic criteria for cerebral infarction or cerebral haemorrhage in the Diagnostic Points of Various Major Cerebrovascular Diseases in China 2019 formulated by the Vascular Disease Group of the Neurology Division of the Chinese Medical Association; (2) Aged between 18 and 65 years old; (3) The onset of the disease is the first time and in the subacute stage, and the duration of the disease is 2 weeks to 3 months; (4) Unilateral stroke, confirmed by CT or MRI; (5) Correctly receiving motor commands, MMSE >24; 6) Presence of trunk postural control disorder, TIS score <=20; 7) Voluntarily participated in the study and signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1) Presence of neurological disorders other than stroke; 2) Brainstem/cerebellar injury; 3) Severe unilateral neglect; 4) Presence of other conditions that may affect trunk postural control, such as history of low back pain, history of low back surgery, acute low back injury and peripheral neuropathy; 5) Presence of contraindications to TMS, such as wearing a pacemaker, having metallic implants in the skull or having a skull defect, previous history of epilepsy, and pregnancy; (6) Combined heart, lung, liver, kidney and other important organs dysfunction or other serious physical diseases.

Design outcomes

Primary

Measure	Time frame
Trunk Impairment Scale;	—

Secondary

Measure	Time frame
Berg balance scale;Function in sitting balance test;Motor evoked potential;surface electromyography;	—

Countries

China

Contacts

Public ContactQiang Gao

West China Hospital, Sichuan University

gaoqiang_hxkf@163.com+86 189 8060 5992

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026