Type 2 diabetes mellitus
Conditions
Interventions
The control group with standard treatment:The control group with standard treatment
The standard treatment plus GLP-1RA (liraglutide) group:GLP-1RA (liraglutide) treatment
The standard treatment plus SGLT-2i (canagliflozin) group:SGLT-2i (canagliflozin) treatment
The standard treatment plus SGLT-1/2i (ixagliflozin) treatment group:The SGLT-1/2i (ixagliflozin) treatment
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Part I Enrollment Criteria: 1. T2DM inclusion criteria: age 18~75 years, meeting the 1999 WHO criteria for diagnosis and classification of diabetes. 2. AS Inclusion Criteria: Age 18~75 years old, with evidence of AS disease in the heart, brain or peripheral vessels, i.e., coronary heart disease (clear history of myocardial infarction> 2 months; Evidence of >=2 coronary arteries or left main stenosis >=50% confirmed by coronary CTA or angiography, with or without revascularization; Presence of evidence of 1 coronary artery stenosis, no revascularization therapy, and a definitive diagnosis of unstable angina >2 months), stroke (history of cerebral infarction or hypertensive intracerebral hemorrhage > 2 months, cerebral infarction or intracerebral hemorrhage confirmed by CT or MRI), or peripheral vascular lesions (atherosclerotic plaques of the lower extremities confirmed by ultrasound or CTA of the lower extremities with > stenosis). =50% and/or have undergone lower extremity arterial intervention, regardless of clinical symptoms) The patients with T2DM enrolled in the MMC of the First Affiliated Hospital of Dalian Medical University were divided into 100 cases in the T2DM group with AS (DAS) and 100 cases in the T2DM group alone (IDM) according to whether there was evidence of AS disease in the heart, brain, and peripheral blood vessels. Part II Enrollment Criteria: Inclusion criteria for T2DM at high risk of cardiovascular disease: age 18~75 years old, meeting the criteria for diagnosis and classification of T2DM, and evidence of cardiac, cerebral or peripheral vascular AS disease (same as Part I. 2. AS Inclusion Criteria).
Exclusion criteria
Exclusion criteria: Diagnosed severe liver and kidney diseases and tumors; recent stress such as ketosis, surgery, trauma or infection; Comorbid severe malnutrition or anemia; combined with acute and chronic gastrointestinal lesions; Hematologic disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical measurement-related outcomes;Laboratory-related outcomes;The primary cardiovascular outcomes;The primary cerebrovascular outcomes;The primary peripheral vascular disease;QCT-related outcomes;Serum SelS outcome; | — |
Countries
China
Contacts
Public ContactShanshan Yu
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed