Sepsis
Conditions
Interventions
Cytokine adsorption therapy group:Adsorption column (CA330)
Sponsors
Xi'an Jiaotong University Second Affiliated Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 16 years; 2. The diagnosis meets the "Third International Consensus Definition of Sepsis and Septic Shock"; 3. Diagnosed as ARDS according to the new definition of ARDS 2023; 4. IL-6 >=1000pg/mL; 5. CVVH/CVVHDF was used for hemofiltration;
Exclusion criteria
Exclusion criteria: 1. Interruption or abandonment of treatment; 2. End-stage renal disease requiring maintenance hemodialysis treatment; 3. People with congenital or acquired immunodeficiency diseases or who have received an organ transplant within 1 year; 4. Coagulation dysfunction within 24 hours, severe bleeding tendency (PT, APTT significantly prolonged with bleeding, or fibrinogen less than 1.2 g/L with bleeding), intracranial hemorrhage or uncontrolled acute hemorrhage; 5. Allergic to materials such as cardiopulmonary bypass, anticoagulation, hemoperfusion or other severe allergic history; 6. Patients identified by the researchers as ineligible for this clinical trial include pregnant or breastfeeding women, HIV positive, drug users, patients with severe sperm disorders, and patients with a history of alcohol abuse that cannot be terminated.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IL-6 clearance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Endotoxin;IL-8;TNF-a;PCT;Lac;The amount of vasoactive drugs used; | — |
Countries
China
Contacts
Public ContactWang Gang
Xi'an Jiaotong University Second Affiliated Hospital
Outcome results
None listed