Depression
Conditions
Interventions
Group B0K0:Blank sound file + normal saline
Group B1K0:Binaural beat music + normal saline
Group B0K1:Blank sound file + esketamine
Group B1K1:Binaural beat music + esketamine
Sponsors
The First Affiliated Hospital of Chongqing Medical University, Chongqing
Eligibility
Sex/Gender
All
Age
19 Years to 59 Years
Inclusion criteria
Inclusion criteria: (1) Patients diagnosed with major depressive disorder who need to be hospitalized for MECT treatment; (2) age 19-59 years; (3) no previous serious comorbidities; (4) American Society of Anesthesiologists (ASA) grade I.-II; (5) Body mass index 18.5-30 kg/m^2; (6) The patient and/or his/her guardian understand and agree, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Combined with serious medical and/or surgical diseases, such as intracranial electrode clips or cardiac pacemakers, etc.; (2) Combined with other psychiatric diseases, such as schizophrenia, etc.; (3) Suffering from diseases or conditions that cannot be completed or affect the efficacy assessment, such as cognitive dysfunction, illiteracy, mental retardation, etc.; (4) There are contraindications to anesthesia or electroconvulsive; (5) Hypertension, risk of intracranial hypertension, hyperthyroidism, severe heart disease or any contraindication to the use of ketamine; (6) Allergy to (es) ketamine; (7) (es) ketamine, or other drug or alcohol dependence; (8) The previous (es) ketamine test was invalid or there were serious adverse reactions; (9) Ineffective or serious adverse reactions of previous MECT therapy; (10) Pregnant women; (11) Participated in other clinical trials within the past 1 year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response rate after MECT treatment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Depression remission rate after MECT treatment;Remission rate of suicidal ideation;Psychotic symptoms associated with depression;Cognitive function;Parameters of electroconvulsive therapy;Perianesthetic vital signs and anesthesia related data;Blood biochemical index; | — |
Countries
China
Contacts
Public ContactJie Luo
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed