Chronic constipation
Conditions
Interventions
Observation group:None
Sponsors
The First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Informed consent voluntarily signed by the subject; 2. Male or female, aged >=18 years old; 3. Meets the Rome IV criteria for functional constipation (FC): Must include two or more of the following: > 25% of the feces feel laborious; >25% of the feces are dry or hard; > 25% of fecal defecation has a feeling of incompleteness; >25% of feces have an anorectal obstruction (or blockage) sensation; >25% of fecal excretions require manual assistance; Spontaneous fecal defecation =75 years old, subjects who meet the above 2-5 inclusion conditions, and their guardians voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Unwillingness to sign informed consent; 2.Those with a prior history of rupiprostenone use; 3.Hypersensitivity to rupiprostenone and its excipients or corkscrew (containing glycerin); 4.Those with a history or significant clinical presentation of mechanical intestinal obstruction (e.g., intestinal tumor or hernia-induced intestinal obstruction); 5.Those with megalorectal/megacolon or pseudo-obstruction; 6.Patients with intestinal tumors; 7.Pregnant and lactating patients; 8.Patients with abnormal liver function and severe renal impairment; 9.Other conditions deemed inappropriate for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of spontaneous bowel movements (SBM); | — |
Countries
China
Contacts
Public ContactYang Hongju
The First Affiliated Hospital of Kunming Medical University
Outcome results
None listed