Hepatocellular Carcinoma
Conditions
Interventions
Sponsors
Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Cohort 1: Age>=18 years; Confirmed diagnosis of unresectable HCC by pathology or imaging; BCLC stage B or C; Child-Pugh score of liver function grade A or B ( 3 months; Signed informed consent. Cohort 2: Age>=18 years; Confirmed diagnosis of HCC by pathology and radical surgical resection; The postoperative pathological stage was stage II or III (AJCC version 8); Child-Pugh score of liver function: grade A; Adjuvant ICI therapy will be started within 4-6 weeks after surgery; ECOG performance status score12 months; Signed informed consent. Cohort 3: Age>=18 years; Diagnosed with HCC by pathology or imaging, assessed as resectable; The clinical stage is stage II or III (AJCC version 8); Child-Pugh score of liver function: grade A; Upcoming neoadjuvant ICI therapy; ECOG performance status score 12 months; Signed informed consent.
Exclusion criteria
Exclusion criteria: Cohort 1: Prior systemic anti-tumor therapy; concurrent malignancy; severe cardiac, pulmonary, or renal dysfunction; current use of antidepressants or anxiolytics; history of psychiatric disorders; symptomatic brain metastases; unable to complete psychological assessment scales. Cohort 2: Residual lesions after surgery; concurrent malignancy; severe cardiac, pulmonary, or renal dysfunction; current use of antidepressants or anxiolytics; history of psychiatric disorders; unable to complete psychological assessment scales. Cohort 3: Prior systemic anti-tumor therapy; concurrent malignancy; severe cardiac, pulmonary, or renal dysfunction; current use of antidepressants or anxiolytics; history of psychiatric disorders; symptomatic brain metastases; unable to complete psychological assessment scales.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Cortisol;Plasma Adrenocorticotropic Hormone;Patient Health Questionnaire-9;Generalized Anxiety Disorder-7 Scale;European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (Version 3); | — |
Countries
China
Contacts
Public ContactYu Yaqun
The Affiliated Hospital of Guilin Medical University
Outcome results
None listed