Intraoperative complications of thoracoscopy
Conditions
Interventions
Esketamine Group (E):The patient was administered 0.2 mg/kg of esketamine during the induction of anesthesia.
Saline placebo group (Group A):The same dose of normal saline was administered during anesthesia induction.
Sponsors
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-65 years old; (2) ASA Grade I ~II; (3) BMI 18-28 kg/m^2; (4) Patients undergoing non-tracheal intubation anesthesia thoracoscopic surgery; (5) Patients who sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients who are allergic to esketamine or have drug contraindications; (2) Secondary surgery or resection of tracheal tumor; (3) A history of neurological disease or mental illness; (4) Preoperative pulmonary function examination FEV1<60% or respiratory system infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of hypoxemia and the time to its onset, with hypoxemia defined as an intraoperative SpO2 <=90% lasting for at least 10 s.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypercapnia (PCO2 >= 60 mmHg);Concentrations of IL-6 and IL-8 at the end of surgery;Postoperative visual analogue scale score;Time to recovery of spontaneous respiration after laryngeal mask placement;Time to laryngeal mask removal (measured from the end of surgery);The awakening time;Incidence of bradycardia (heart rate [HR] 20% reduction in blood pressure from the baseline value);Incidence of = 24 h postoperative nausea and vomiting and hoarseness;Time to ambulation, drinking, and eating postoperatively;Incidence of pulmonary complications within 2 weeks postoperatively;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactGu Changping
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Outcome results
None listed