Sepsis associated-acute kidney injury
Conditions
Interventions
Acute kidney injury :None
Non acute kidney injury:None
Sponsors
Jining No.1 People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion/exclusion criteria; Subjects: Adult patients diagnosed with sepsis within 24 hours of admission. Diagnostic criteria: (1) The diagnostic criteria for sepsis are SEPSIS 3.0 criteria, that is, a rapid increase in SOFA score after infection >=2 as the clinical judgment criterion for organ dysfunction in sepsis. (2) The diagnostic criteria for acute kidney injury follow the latest KDIGO guidelines, including the diagnosis of AKI in one of the following conditions: 1) an increase in Scr of more than 26.5 micromol/L (0.3 mg/dl) within 48 hours; 2) SCR elevation greater than 1.5 times baseline – confirmed or presumed to occur within 7 days; 3) Urine output < 0.5ml/(kg·h) for more than 6 hours. (3) Acute kidney injury following the onset of sepsis in patients is defined as SA-AKI.
Exclusion criteria
Exclusion criteria: 1.Presence of other underlying kidney diseases, such as chronic renal insufficiency, adrenocortical insufficiency, etc.; 2.Presence of patients with acute cardiovascular and cerebrovascular diseases that lead to death within 24 hours; 3.Patients who have previously undergone kidney transplantation or kidney surgery; 4.Pregnant or lactating women; 5.Patients with intellectual or psychological disabilities who are not suitable for participating in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of S100A12 in plasma;S100A12 transcription level differences; | — |
Countries
China
Contacts
Public ContactJikui Shi
Jining No.1 People's Hospital
Outcome results
None listed