Bloodstream Infection
Conditions
Interventions
ddPCR Group:Perform digital PCR testing and use antibiotics based on the results
Control Group:Perform standard testing and use antibiotics based on the results
Sponsors
West China Tianfu Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Over 18 years old, the patient or his / her legal agent shall sign the informed consent form on the day of enrollment; 2.Patients who were admitted to the ICU; 3. Clinical suspicion of bloodstream infection, and blood culture test, at least meet the following two points: 3.1 The highest body temperature is> 38.3?; 3.2 The increase in white blood cell count is hardly explained by non-infectious factors; 3.3 The increase in CRP / ESR / FER values is difficult to be explained by non-infectious factors; 3.4 The increase in PCT value cannot be not easily explained by non-infectious factors; 3.5 BSI risk factors: (i) advanced age (65 years) and (ii) immunosuppression. In the past few months, immunosuppressants, including glucocorticoids, or combined complications (such as tumors, especially cancer, kidney failure, liver failure, AIDS, no spleen, etc.). In addition, diabetes and obesity were considered as they may alter the immune system and increase the risk of BSI. And (iii) a previous diagnosis or a family history of immunodeficiency.(And iv) approximately 50% of intensive care patients have nosocomial infection. And (v) Invasive procedures such as mechanical ventilation and endovascular catheterization.
Exclusion criteria
Exclusion criteria: 1) The patient information is not entered into the electronic medical record system; 2) Refuse to draw blood or refuse to participate in the test; 3) Mental disorders or pregnant women; 4) Participated in other clinical trials; 5) Expected length of hospital stay is <72h.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| relative change in SOFA score on day 7 or ICU discharge / death versus day 0; | — |
Secondary
| Measure | Time frame |
|---|---|
| consumption of antimicrobial agents during ICU stay (in daily dose);days from enrollment to targeted antimicrobial therapy;overall antimicrobial use and cost;total hospitalization costs;ICU, hospital stay;mortality rate of 28 and 90 days;duration of mechanical ventilation or vasoactive drug application; | — |
Countries
China
Contacts
Public ContactXuelian Lian
West China Tianfu Hospital, Sichuan University
Outcome results
None listed