Helicobacter pylori infection
Conditions
Interventions
Standard treatment group:Patients in the standard treatment group were treated with standard eradication therapy for 2 weeks, and UBT was re-examined after 4 weeks of drug withdrawal
Concomitant treatment group:The fermented milk was taken at the same time as the eradication treatment drug for 2 weeks, and the UBT was re-examined 4 weeks after all treatment.
Sequential treatment group:The fermented milk was taken for 2 weeks before standard eradication therapy, and the UBT was re-examined 4 weeks after all drugs was stopped
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Treatment-naïve (untreated) patients with Hp infection diagnosed by molecular pathology or C13 breath test (13C-UBT); (2) Age 18-75 years old; (3) Agree and conditionally retain fecal and saliva samples; (4) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Severe liver and kidney insufficiency, cardiopulmonary insufficiency, malignant tumors, autoimmune diseases, mental or cognitive dysfunction; (2) Patients with gastric or esophageal surgery; (3) Pregnant and lactating women (women of childbearing age should take contraceptive measures during medication); (4) Known allergy to one or more of P-CAB and bismuth; (5) Use of antibiotics, bismuth, probiotics within 4 weeks or H2 receptor antagonists, proton pump inhibitors (PPIs) or P-CABs within 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in intestinal and oral microbiota composition and metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Eradication rates;GSRS score; | — |
Countries
China
Contacts
Public ContactShiyu Du
China-Japan Friendship Hospital
Outcome results
None listed