Stress and inflammation
Conditions
Interventions
High NOx value group without underlying diseases:The intraoperative NOX value was maintained at 40-49
High NOx value group without underlying diseases:The intraoperative NOX value was maintained at 30-39
Hypertension alone high NOX value group:The intraoperative NOX value was maintained at 40-49
Diabetes mellitus alone high NOX value group:The intraoperative NOX value was maintained at 40-49
Diabetes mellitus alone high NOX value group:The intraoperative NOX value was maintained at 30-39
Low NOX group with simple coronary heart disease:The intraoperative NOX value was maintained at 30-39
Pure coronary heart disease high NOX value group:The intraoperative NOX value was maintained at 40-49
Compound two or more diseases in the high NOX value group:The intraoperative NOX value was maintained at 40-49
Compound two or more diseases in the low NOx group:The intraoperative NOX value was maintained at 30-39
Sponsors
Department of Anesthesiology, Affiliated Hospital of Hebei University
Eligibility
Sex/Gender
Female
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Age 18~90 years old; 2) American Society of Anesthesiologists ASA grade I.~III.; 3) The operation time is more than 120min; 4) Patients and their families understand the purpose of the study and sign the informed consent form; Obtain approval from the Ethics Committee;
Exclusion criteria
Exclusion criteria: 1) Patients with American Society of Anesthesiologists ASA grade III or above; 2) Patients who are receiving immune-related therapy before surgery and have recently taken steroidal or hormone-related drugs; 3) Patients with severe hepatic and renal insufficiency, peripheral vascular disease or contraindication to arterial catheterization; 4) Patients receiving radiotherapy and chemotherapy before surgery 5) patients whose surgery was changed from laparoscopy to laparotomy; 6) Patients undergoing emergency surgery or secondary surgery 7) Patients with poor compliance who are expected to be unable to complete the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cortisol;Interleukin-1ß;Interleukin-10;VisualAnaloguScale;postoperative nausea and vomiting;Drowsiness;infect;Length of postoperative hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;heart rate;Refers to pulse oxygen; | — |
Countries
China
Contacts
Public ContactLiLu
Department of Anesthesiology, Affiliated Hospital of Hebei University
Outcome results
None listed