Tonsil or adenoids hypertrophy
Conditions
Interventions
Remimazolam group 0:The predetermined dose of remimazolam in the first case was set at 0.8 mg/kg/h. The subsequent dose of remimazolam was determined according to the BC method based on the response o
Rimazolam group:Infusion of remimazolam besylate
Dexmedetomidine group:Infusion of Dexmedetomidine
Normal saline group:Infusion of Normal saline
Sponsors
The Affiliated Women's and Children's Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
3 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1. Age: 3~7 years old; 2. ASA classification: 1~II; 3. Tonsillectomy and/or adenoidectomy under general anesthesia is planned to be elective.
Exclusion criteria
Exclusion criteria: 1. ASA Grading > II; 2. Preoperative respiratory tract infection; 3. Recovery room accident (such as airway spasm, wound bleeding, etc.); 4. Allergy to remimazolam, an A2-adrenergic receptor agonist; 5. Abnormal liver and kidney function, abnormal cardiac function, sinus bradycardia (heart rate less than 60 beats/min); 6. Neurological or psychiatric disorders including children with a history of epilepsy, developmental delays, or autism; 7. History of multiple (>=3) surgeries, use of anticonvulsant, sedative or analgesic drugs within 2 weeks; 8. Severe sleep apnea (sleep apnea index >=5.0); 9. Guardian refuses to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Emergence Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain;Rescue times and dosage of propofol; | — |
Countries
China
Contacts
Public ContactZhongsai Yang
The Affiliated Women's and Children's Hospital of Ningbo University
Outcome results
None listed