Postoperative rehabilitation
Conditions
Interventions
Experimental group:Dilute 2mg/kg of nalbuphine and 1 µ g/kg of sufentanil citrate with physiological saline to 100ml for postoperative analgesia. Parameter settings: background dose 2ml/h, bolus 0.5ml
control group:Dilute 2 µ g/kg of sufentanil citrate with physiological saline to 100ml for postoperative analgesia. Parameter settings: background dose 2ml/h, bolus 0.5ml/time, locking time 15min. Mai
Sponsors
Qingdao Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: ASA I-III grade patients aged = 18 years, undergoing elective spinal surgery OLIF under general anesthesia, with a BMI = 18.5 kg/m and a weight of 29 kg/m2
Exclusion criteria
Exclusion criteria: 1) Poor compliance and inability to cooperate with surgery; (2) Patients with severe organic lesions (coronary heart disease, bronchial asthma, severe hypertension, severe hematological dysfunction, liver and kidney function, and significant electrolyte abnormalities); (3) Grade II and above atrioventricular block, bradycardia (HR<50 beats/minute), hypotension (SBP<90mmHg); (4) History of neurological disorders; History of chronic pain; Drug addiction and alcoholism; Long term history of opioid use; (5) Individuals allergic to components of nalbuphine hydrochloride or sufentanil, and patients with a history of opioid allergy; (6) Patients with limited gastric emptying and gastroparesis; (7) Patients with weakened intestinal peristalsis and intestinal obstruction; (8) Individuals who have participated in clinical trials of other drugs within the past 4 weeks; (9) Accompanied by other circumstances, the researchers believe that patients who are not suitable for inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative QoR-15 scores on day 1, 3, and 5;Postoperative patient satisfaction related indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain related indicators;Postoperative recovery indicators; | — |
Countries
China
Contacts
Public ContactXu Lin
Qingdao Municipal Hospital
Outcome results
None listed