Perioperative psychiatric disorders
Conditions
Interventions
Group V0K0:normal saline ivgtt.+ normal saline iv.
Group V0K1:normal saline ivgtt.+ esketamine iv.
Group V1K0:Vitamin C ivgtt.+normal saline iv.
Group V1K1:Vitamin C ivgtt.+ esketamine iv.
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) 18 < age <=45 years, ASA classification I-II, 18.5<=BMI < 30 kg/m^2; (2) receive painless abortion under intravenous general anesthesia; (3) The patient and/or guardian understood and agreed to sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) ASA classification>= 3; (2) complicated with serious diseases (such as uncontrolled hypertension, uncontrolled diabetes, severe heart, liver, kidney, lung dysfunction or any contraindications to ketamine/esketamine); (3) allergy to vitamin C and esketamine; (4) history of mental illness; (5) history of antipsychotic medication; (6) neurological dysfunction (including sleep disorders); (7) epilepsy; (8) history of ketamine/esketamine abuse or dependence; (9) previous trials of esketamine were ineffective or had serious adverse reactions; (10) drug or alcohol dependence; (11) acute genital inflammation, such as vaginitis, pelvic inflammatory diseases; (12) failure of drug induction of labor; (13) suffering from diseases or conditions that could not complete or affect the efficacy evaluation, such as cognitive impairment, illiteracy, mental retardation, etc.; (14) participated in other clinical trials within the past 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of post-abortion depression assessed by Edinburgh Postnatal Depression Scale (EPDS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Edinburgh Postnatal Depression Scale (EPDS) depression scale score;Self-Rating Anxiety Scale score;Insomnia Severity Index (ISI) score;Numerical rating scale score;Postoperative use of analgesics;Monitoring of intraoperative vital signs etc;The amount of anesthetic drugs used during the operation;Patient satisfaction;Blood Vitamin C levels;Hospital Anxiety and Depression Scale (HADS) score;Sleep Quality Numeric Rating Scale (SQ-NRS) score; | — |
Countries
China
Contacts
Public ContactJie Luo
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed