Neural Mechanism of brain-computer interface training to improve wrist and hand motor function via sensorimotor interaction in stroke patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400094693

Enrollment

Unknown

Registered

2024-12-26

Start date

2025-01-01

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Multi-sensory input BCI training group:Conventional rehabilitation therapy combined with multi-sensory input BCI training

Visual input BCI training group:Conventional rehabilitation therapy combined with visual input BCI training

Motor imagery combined with tactile sensory input training group:Conventional rehabilitation therapy combined with motor imagery with tactile sensory input

Healthy Participants Group:None

Stroke Group:None

Eligibility

Sex/Gender

All

Age

20 Years to 75 Years

Inclusion criteria

Inclusion criteria: Stroke patients 1. Age between 20 to 75 years old 2. Diagnosis in accordance with the key criteria point rasied in 2019 conference 3. Confirmed by CT or MRI of the brain 4. Without serious cognitive impairment, MoCA>=26 5. Without auditory or visual impairment 6. Paretic wrist motor impairment (FMA<46, no active wrist motion, MEP of the paretic side could not be induced), and disease duration above 6 months 7.Willing to sign informed consent 8. Vital signs stable Healthy Participants 1.Age between 20 to 75 years old 2.Healthy, without diagnosis of neurological or mental illness

Exclusion criteria

Exclusion criteria: Stroke patients 1. Obvious cognitive, auditory or visual impairment 2. Patients with metal in the body (pacemaker, arterial stent, etc.) 3. Those cannot complete MRI examination or rTMS assessments 4. Pregnant or lactating women 5. Those with severe cardiopulmonary, liver, kidney and endocrine dysfunction who are not suitable for rehabilitation training. Poor compliance and unable to complete this training. Healthy Participants 1. Obvious cognitive, auditory or visual impairment 2. Patients with metal in the body (pacemaker, arterial stent, etc.) 3. Those cannot complete MRI examination or rTMS assessments 4. Pregnant or lactating women 5. Those with severe cardiopulmonary, liver, kidney and endocrine dysfunction who are not suitable for rehabilitation training. Poor compliance and unable to complete this training.

Design outcomes

Primary

Measure	Time frame
Fugl-Meyer score of upper extremity;	—

Secondary

Measure	Time frame
Arm Movement Research Test;Upper limb motor index;muscle strength;muscle tone;active ROM;sensory assessment;sEMG;evoked potentials(MEP,,SEP);EEG;MRI(fsMRI,functional MRI,,DTI);	—

Countries

China

Contacts

Public ContactLu Rongrong

Huashan Hospital Fudan University

0356213@fudan.edu.cn+86 21 5288 7820

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026