Elderly patients who require general anesthesia and endotracheal intubation
Conditions
Interventions
S group:Remimazolam 0.2mg/kg + sufentanil 0.4ug/kg + propofol 2mg/kg
E group:Remimazolam 0.2mg/kg + esketamine 0.5mg/kg + propofol 2mg/kg + lidocaine 1.5mg/kg
Sponsors
Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patient age: 60-80 years old, gender is not limited, body mass index (BMI) is 18.5-25kg/m²; (2) Patients are awake before surgery, elective surgery and anesthesia requires general anesthesia with endotracheal intubation; (3) American Society of Anesthesiologists (ASA) grade I-III and Mallampati airway grade I-II before surgery; (4) No serious heart, lung, brain and other important organ diseases, no obvious abnormalities in liver and kidney function; (5) Clearly understand the research content of this study before surgery and voluntarily participate, and sign the informed consent form;
Exclusion criteria
Exclusion criteria: (1) Patients with severe heart, lung, liver, or kidney dysfunction or severe cardiovascular and cerebrovascular diseases; (2) Patients with high-grade atrioventricular block who need to be implanted with a pacemaker; (3) Patients with sinus tachycardia or severe arrhythmia; (4) Patients with poorly controlled or untreated hypertension (resting systolic/diastolic blood pressure >180/100 mmHg); (5) Patients with known allergies to the anesthetics used in this study or with a history of severe allergies; (6) Patients who have long-term use of nonsteroidal anti-inflammatory drugs, narcotic analgesics, or sedatives; (7) Patients with mental illness and consciousness; (8) Patients who have taken hormone drugs before surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial pressure, MAP;Bispectral Index (BIS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood gas analysis (blood sugar, blood lactate);Number of cases of additional propofol during intubation;Use of vasoactive drugs;Incidence of adverse events (choking, injection pain, hypertension, hypotension, tachycardia, bradycardia, nausea and vomiting, delayed awakening); | — |
Countries
China
Contacts
Public ContactXu Jinhui
Jiangxi Provincial People's Hospital (The First Affiliated Hospital of Nanchang Medical College)
Outcome results
None listed