Disturbance of consciousness after brain injury
Conditions
Interventions
tDCS Awakening Group:The anode of tDCS is placed over the dorsolateral prefrontal cortex of the dominant hemisphere (the left side), specifically at the location F3 according to the international 10-2
MNS Awakening Group:One patch of the median nerve electrical stimulation device is placed on the median nerve, located 2 cm above the transverse palmar crease of the patients right wrist. The other pa
Combined Awakening Group:Administer tDCS therapy simultaneously during MNS therapy
Sponsors
Jinhua Hospital of TCM Afliated to Zhejiang University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for head injury (including stroke and traumatic brain injury): stroke meets the diagnostic criteria for stroke revised by the Fourth National Academic Conference on Cerebrovascular Diseases (1995), and is confirmed by head CT or MRI. Traumatic brain injury has a clear history of head trauma, CT or MRI confirmed the diagnosis of diffuse axonal injury, brainstem injury, subdural (external) hematoma, cerebral contusion, etc. caused by traumatic brain injury; (2) meet the diagnostic criteria for chronic impairment of consciousness; According to the "Chinese Expert Consensus on the Diagnosis and Treatment of Chronic Consciousness Disorders" formulated by the Consciousness Disorder and Awakening Promotion Group of the Neurorepair Professional Committee of the Chinese Medical Doctor Association, the state of loss of consciousness caused by various severe brain injuries, such as coma, vegetative state and microconscious state, and the loss of consciousness for more than 28 days; (3) Age 18-70 years old; (4) Stable vital signs; (5) Family members or authorized representatives agree to participate in the research of this topic and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with serious complications of respiratory, circulatory and other systems, and unstable vital signs; (2) Patients with status epilepticus; (3) Patients with intracranial infection; (4) Age greater than 70 years old or less than 18 years old; (5) CT or MRI showed obvious cerebral edema; (6) Family members or their guardians are unwilling or unable to cooperate with the treatment and refuse to fill in the Informed Consent Form; (7) Those who are unstable and suffer from other serious heart, lung, liver and kidney diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma Recovery Scale-Revised;Brainstem Auditory Evoked Potential;Event-related Potential; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glasgow Coma Scale;Average eye opening time;White blood cell count;C-reactive protein; | — |
Countries
China
Contacts
Public ContactLingyan Wang
Jinhua Hospital of TCM Afliated to Zhejiang University of Traditional Chinese Medicine
Outcome results
None listed