Cerebral palsy
Conditions
Interventions
Gold Standard:At present, the main diagnostic methods for cerebral palsy include whole-body motor quality assessment (GMs), Hammersmith infant neurological examination (HINE), and infant neurodevelopm
Index test:GMs, HINE, MRI, and infant neurodevelopmental assessment tools and professional clinical diagnosis
Sponsors
Children's Hospital,Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. Infants aged 3 days to 5 months, regardless of gender; 2.High-risk factors for cerebral palsy and neurodevelopmental impairment: including multiple pregnancies, intracranial hemorrhage, intracranial infection, neonatal hypoxic ischemic encephalopathy, perinatal asphyxia, low birth weight, hyperbilirubinemia, etc; 3.Abnormal neurological examination: such as abnormal muscle tone, abnormal posture, abnormal reflexes; 4.Two qualified senior therapists who have completed the GMs Trust training course determine the high-risk infants of cerebral palsy using the gold standard assessment for cerebral palsy - the Global Movement Assessment Scale (GMs), including the presence of global movement disorder, spastic synergy, monotony, and asymmetry before term or during the fetal movement stage,the presence of abnormal hyperactivity and the absence of restlessness; 5.Children aged 1 and 2 have a clear follow-up outcome: determined to have cerebral palsy, including the following four essential conditions: (1) persistent central motor dysfunction;(2).abnormal development of movement and posture;(3). abnormal muscle tone and muscle strength;(4). abnormal development of reflexes; 6. Have not received any relevant drugs within the past 3 months; 7.The patient and parents agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Currently participating in other clinical trials; 2.Diagnosed with Rett syndrome or fragile X syndrome through genetic testing or clinical diagnosis; 3.Patients with severe or unstable physical conditions, including cardiovascular diseases, tumors, kidney diseases, secretory diseases (including thyroid dysfunction), gastrointestinal diseases, hematological diseases, and neurological diseases; 4.The attending physician or researcher believes that there are other circumstances that are not suitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cerebral palsy; | — |
Countries
China
Contacts
Public ContactJinpiao Zhu
Children's Hospital,Zhejiang University School of Medicine
Outcome results
None listed