acute myeloid leukemia
Conditions
Interventions
treatment group:Alternate treatment with VA and AZA+HAG regimen
Sponsors
Shenzhen second people‘s hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Newly diagnosed AML patients; 3. Meet the criteria of not suitable for intensive chemotherapy: if the patient is >=60 years old, the patient is considered not suitable for intensive chemotherapy; If the patient is less than 60 years of age, but is not considered appropriate for intensive chemotherapy, including: (a) a lung infection requiring treatment; (b) Hepatic insufficiency (total bilirubin >=2 times the upper limit of normal [ULN] or alanine aminotransferase or aspartate aminotransferase >=2 times the ULN); (c) Renal insufficiency (creatinine >=2×ULN or creatinine clearance =2. 4. Patients who agree to sign and provide informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with other malignant tumors; 2. Immunomodulatory therapy, demethylation drugs, chemotherapy and other treatments within 3 months; 3. Patients with a history of severe heart disease; 4. Patients with severe liver and kidney dysfunction; 5. Patients with unclear consciousness or mental disorders can not cooperate with diagnosis and treatment; 6. Allergic to therapeutic drug ingredients; 7. Acute promyelocytic leukemia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| composite complete remission rate after 4 cycles; | — |
Secondary
| Measure | Time frame |
|---|---|
| objective response rate (ORR) after 4 cycles;relapsed free survival;overall survival;safety; | — |
Countries
China
Contacts
Public ContactGuangyang Weng
Department of Hematology, Shenzhen Second People's Hospital
Outcome results
None listed