Heatstroke
Conditions
Interventions
Hypothermia group:Induced low temperature, target temperature 35 ?
a. Cooling stage: Adopt any one or a combination of the following measures to cool down
Ice blanket, fan, cold water bag, cold plasti
Normothermia:conventional therapy
a. The diagnosis and treatment strategy determined by the attending physician.
b. Do not intervene in the patients body temperature if it does not exceed 37.5 ?
c. I
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign the informed consent form and comply with the requirements of the protocol; 2. Age range of 18 to 75 years old (including 18 and 75 years old); 3. Satisfy any medical history information and any clinical presentation, and the patient's clinical presentation cannot be explained by other reasons: Medical history information: a. Exposure to high temperature and high humidity environments (relative humidity above 90%, temperature above 30 degrees Celsius); b. High intensity exercise (equivalent to brisk walking at around 7 kilometers per hour, jogging at least 8 kilometers per hour, and cycling at around 20 kilometers per hour) Clinical manifestations: a. Symptoms of central nervous system dysfunction (such as coma, convulsions, delirium, abnormal behavior, etc.) b. Core temperature exceeds 40 ?; c. Multiple organ (= 2) functional damage manifestations (liver, kidney, striated muscle, gastrointestinal tract, etc.); d. Severe coagulation dysfunction or DIC; 4. The exposure time to high temperature and high humidity environment or the start time of high-intensity exercise should not exceed 24 hours from the ICU admission time; 5. Tracheal intubation due to consciousness impairment (FOUR score less than 4 points); 6. Expected tracheal intubation time greater than 48 hours.
Exclusion criteria
Exclusion criteria: 1. Patients with combined central nervous system diseases, including cerebral hemorrhage, extensive cerebral infarction, subarachnoid hemorrhage, and cerebral infarction, inflammation, meningitis, epilepsy, etc; 2. It cannot be ruled out that multiple organ failure is caused by infection in patients; 3. Patients with hypoglycemic coma, hyperosmolar coma, hepatic encephalopathy, and uremic encephalopathy; 4. Pregnant or lactating women; 5. Patients with chronic COPD requiring long-term oxygen therapy; 6. Life expectancy is less than 48 hours; 7. Has participated in other clinical studies; 8. Other situations that researchers believe are not suitable for participating in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 days after randomization, the proportion of patients with poor functional results was measured using the mRS scale (mRS 0-3 and 4-6); | — |
Secondary
| Measure | Time frame |
|---|---|
| 28 day all-cause mortality rate;Incidence of organ failure within 28 days: Renal failure, respiratory failure, circulatory failure, neurological dysfunction, liver failure, coagulation dysfunction;Quality of life: HRQoL; | — |
Countries
China
Contacts
Public ContactQin Wu
West China Hospital of Sichuan University, Wuhou District, Chengdu City, Sichuan Province, China
Outcome results
None listed