respiratory distress syndrome
Conditions
Interventions
improved INSURE:Continue to provide continuous mechanical ventilation for about 1 hour after injecting PS
MIST:After completing the PS administration, remove the tube and withdraw the gastric contents from the gastric tube to understand the reflux of PS into the digestive tract.
Sponsors
Department of Pediatrics , Suining County People ' s Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria Those who meet the following conditions simultaneously: (1) live born newborns with gestational age=30% is required to maintain a transcutaneous pulse oxygen saturation of 90% to 94%;(5) Obtain informed consent from the guardian.
Exclusion criteria
Exclusion criteria: Exclusion criteria: (1) Regular or high-frequency mechanical ventilation is required before enrollment; (2) Vital signs are extremely unstable; (3) Congenital respiratory malformations (such as posterior nasal atresia, cleft palate, tracheoesophageal fistula, etc.); (4) Severe cyanotic congenital heart disease (such as transposition of the great arteries, Tetralogy of Fallot, etc.); (5) Severe congenital malformations (such as Trisomy 21 syndrome, congenital diaphragmatic hernia, omphalocele, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the duration o respiratory support,DRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of first use of pulmonary surfactant;Pulmonary surfactant injection time;Total operating time;Number of times pulmonary surfactant is used;post administration blood gas analysis results;Delay extubation for 1 hour and recheck chest X-ray results;Number of cases of mechanical ventilation with endotracheal intubation within 72 hours;Number of apnea;Time for non-invasive and invasive respiratory support;hemodynamically significant patent ductus arteriosus,hsPDA;Sepsis ;intraventricular hemorrhage,IVH;periventricular leukomalacia,PVL;Airleak syndrome;necrotizing enterocolitis, NEC;bronchopulmonary dysplasia,BPD;retinopathy of premature,ROP;Hospitalization duration and mortality rate; | — |
Countries
China
Contacts
Public ContactTong Shi
Suining County People's Hospital
Outcome results
None listed