Premature
Conditions
Interventions
Control:Routine clinical care and monitoring
Treatment group:Receive DSM17938 and routine clinical treatment
Sponsors
Southern Medical University Southern Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1) Preterm infants with a gestational age of less than 37 weeks. 2) Infants with a birth weight of less than 2500 grams.3)Admission to the hospital within 72 hours after birth. 3)Signed informed consent form by parents or legal guardians.
Exclusion criteria
Exclusion criteria: 1)Congenital gastrointestinal malformations, inherited metabolic diseases, or congenital immunodeficiency diseases. 2)History of severe asphyxia, infection, or hepatic or renal insufficiency at birth/enrollment. 3)Death within 72 hours after birth.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ability of NOD2 receptor to activate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Gut /Oral microbiome;Colonization rate of Lactobacillus reuteri DSM17938; | — |
Countries
China
Contacts
Public ContactWei Shen
Southern Medical University Southern Hospital
Outcome results
None listed