Depression
Conditions
Interventions
Normal control group:None
MDD group (MDD-A group)---MDD-Rgroup:None
Sponsors
Jiangxi Mental Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 55 Years
Inclusion criteria
Inclusion criteria: Select a total of 50 patients with acute depression (MDD group) who visited the outpatient or inpatient department of Jiangxi Provincial Mental Hospital from January 2025 to December 2025 and were in the acute attack stage, The MDD group was enrolled in the acute depressive episode phase, hence also marked as the MDD-A group. The MDD-A group, which entered the remission and recovery phase after clinical treatment, was marked as the MDD-R group; Select 50 age and gender matched healthy individuals (CON group). 1. Inclusion criteria: 1.1. MDD group: The MDD group was enrolled during the acute phase of depression, hence it is referred to as the MDD-A group; (1).Meets the diagnostic criteria for "depressive disorder" in the 11th edition of the International Classification of Diseases and Related Health Problems (ICD-11); And all patients were first diagnosed, did not receive antidepressant treatment, or stopped taking any antidepressant medication at least 3 months before participating in the study; (2). Evaluate Hamilton Depression Rating Scale (HAMD-24) score>20 points by at least 2 psychiatrists; (3). Normal vision or corrected vision, no color blindness or other ophthalmic diseases, no facial expression recognition disorders, no difficulty in verbal communication, able to complete eye movement experiments; (4). Right handed, aged between 16 and 55, with a junior high school education or above (capable of implementing MCCB); (5).Patients or their families are informed and voluntarily participate in the experiment, and sign informed consent forms; (6).Voluntarily participate and truthfully fill out the general information and suicidal ideation/behavior inquiry form self-made by the researchers; 1.2. The criteria for entering the remission and recovery period (MDD-R group) after clinical treatment in the MDD-A group are: after treatment (approximately 4-6 weeks after treatment), through doctor interviews and evaluations, HAMD-24 score = 50%; 1.3. CON group: Meets the HAMD-24 score of<8 points, and the other inclusion criteria are the same as those of MDD group (3), (4), (5), and (6).
Exclusion criteria
Exclusion criteria: The exclusion criteria for MDD group and CON group are the same. 1.Exclude patients with depression accompanied by brain organic diseases, severe physical illnesses, dependence on psychoactive substances, stress-related disorders, and secondary to other organic diseases; 2. Exclude patients with comorbidities of other serious psychiatric disorders (such as schizophrenia, bipolar disorder, etc.), non suicidal suicide, self injury and suicide caused by personality disorders, or severe excitement accompanied by hallucinations and delusions, as well as those who have taken psychoactive substances before the test; 3. Those who should have hypertension, diabetes and other organic factors and cannot tolerate eye movement test, MCCB test and blood drawing; 4. According to the assessment of a psychiatrist, patients with strong depressive suicidal/self injurious ideation, impulsive behavior that has caused severe physical damage, and are unable or temporarily unable to undergo eye tracking and MCCB testing; 5. According to the assessment of a psychiatrist, although the patient has been diagnosed with depression in the past, there is a tendency and possibility of a "soft biphasic" diagnosis in their recent medical history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-24 rating;Pay attention to biased scores;MATRICS Consensus Battery rating;GRP78,CHOP, Bax and BDNF in the peripheral blood; | — |
Countries
China
Contacts
Public ContactZhang Jing
Jiangxi Mental Hospital
Outcome results
None listed