cranial defect
Conditions
Interventions
Group E:Early cranioplasty (within 3 months of decompressive craniectomy)
Group L:late cranioplasty (beyond 3 months)
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 18 and 65 years; (2) Have a skull defect size greater than 25 cm^2 (diameter greater than 5cm); (3) The skull defect must have resulted from one of the following conditions, which will be recorded for each patient: severe traumatic brain injury, malignant ischemic stroke, hemorrhagic stroke, or an infiltrative tumor; (4) Provide informed consent to participate in the study, either personally or through a legally authorized representative.
Exclusion criteria
Exclusion criteria: (1) Exhibit poor healing from the initial decompressive craniotomy surgeries; (2) Have uncontrolled intracerebral infections , defined as an infection that persists despite standard antibiotic treatment; (3) Have untreated intracranial hematoma; (4) Are deemed unsuitable for surgery due to poor general health conditions; (5) Present with hydrocephalus; (6) Are pregnant at the time of recruitment; (7) Have a clinical diagnosis of being in a minimally conscious state or a vegetative state.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Barthel Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| EQ-5D scale;Glasgow Outcome Scale (GOS);Postoperative complications; | — |
Countries
China
Contacts
Public ContactJunwen Guan
Department of Neurosurgery, West China Hospital of Sichuan University
Outcome results
None listed