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Modulation of JAK-STAT signaling to rescue hematopoietic stem and progenitor dysfunction in chronic granulomatous disease (CGD)

Modulation of JAK-STAT signaling to rescue hematopoietic stem and progenitor dysfunction in chronic granulomatous disease (CGD)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400094610
Enrollment
Unknown
Registered
2024-12-25
Start date
2025-01-01
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic granulomatous disease (CGD)

Interventions

Chronic granulomatous disease group:NA
Healthy hematopoietic stem cell donors:NA

Sponsors

The University of Hongkong - Shenzhen Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1.Diagnosed with chronic granulomatous disease; 2.confirm the CYBB gene mutation by Genetic testing; 3.G-CSF stimulus factor was used, autologous stem cell collection; 4.Age <= 18 years;

Exclusion criteria

Exclusion criteria: 1.Other primary immunodeficiency disorders; 2.Autoimmune inflammatory diseases; 3.Rheumatic diseases; 4.Hematological neoplasms, malignant diseases;

Design outcomes

Primary

MeasureTime frame
hematopoietic stem and progenitor dysfunction;—

Countries

China

Contacts

Public ContactWeiLing Liang

The University of Hongkong - Shenzhen Hospital

liangwl@hku-szh.org+86 15899850499

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026