Alzheimer's disease
Conditions
Interventions
Experimental group:Bilateral jugular deep lymphatic venous anastomosis was performed.
control group:Non operative treatment (conservative treatment).
Sponsors
The First People's Hospital of Zunyi City
Eligibility
Sex/Gender
All
Age
50 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Meet the above clinical diagnostic criteria and symptom staging criteria for Alzheimer's disease; (2) Subject age> 50 years old; (3) The course of the disease > 6 months; (4) The comprehensive score of the Clinical Dementia Rating Scale (CDR) is 2 or 3 points, that is, moderate dementia or severe dementia; (5) The Mini-Mental State Examination (MMSE) score is 10~15 points, accompanied by dementia mental and behavioural symptoms (BPSD) (6) No history of mental illness and epilepsy in the past, and no serious diseases of other organs, i.e., systems: (7) Patients and their families have understood the purpose, significance, expected effects and potential risks of this study in detail and voluntarily joined the trial, and signed the relevant informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with non-AD or mild AD; (2) Those who suffer from other mental illnesses or cognitive dysfunction due to depression, Parkinson's, cerebral infarction and other diseases; (3) Combined tumours, cardiovascular and cerebrovascular diseases, bleeding diseases, severe liver and kidney insufficiency, etc.; (4) Those who have received relevant treatment within 1 month of participating in this study: (5) The use of multinepezil, mannute sodium capsule (GV-971), and olanzapine within 3 months of participating in this study to affect cognitive and psychiatric symptoms; (6) Those who cannot tolerate cervical lymph node-venous anastomosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini Mental State Examination (MMSE) score;Alzheimer's Disease Assessment Scale Cognitive Scale (ADAS Cog) score;Activities of Daily Living Scale (ADL) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Aß protein;Tau protein;inflammatory factors; | — |
Countries
China
Contacts
Public ContactFu Xiaohong
The First People's Hospital of Zunyi City
Outcome results
None listed