Prediction of lymphatic vascular infiltration before breast cancer based on MRI-OGSE multifunctional diffusion imaging to support surgical decision-making multi-center study

Prediction of lymphatic vascular infiltration before breast cancer based on MRI-OGSE multifunctional diffusion imaging to support surgical decision-making multi-center study - MRI-OGSE-based Prediction of Preoperative Lymphovascular Invasion in Breast Cancer for Surgical Decision Support: A Multicenter Study

Status

Recruiting

Phases

Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400094589

Enrollment

Unknown

Registered

2024-12-25

Start date

2024-12-31

Completion date

Unknown

Last updated

2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

Training Group:null

External Validation Group:null

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Pathologically diagnosed invasive breast cancer patients with LVI status confirmed through postoperative pathological examination of tissue samples. 2.Imaging characteristics meeting the required criteria, including T2-weighted imaging (T2WI) with fat suppression, Diffusion-weighted imaging (DWI), T1-weighted imaging, T1 dynamic contrast-enhanced imaging, and the IMPULSED sequence based on Quantitative Temporal Diffusion Spectroscopy Imaging (qTDSI). 3.Patients who undergo breast mastectomy or breast tumor resection within two weeks after MRI scanning. 4.Patients who have signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with poor MRI image quality or the presence of artifacts. 2.Patients who have undergone neoadjuvant chemotherapy prior to surgery. 3.Patients who have had a breast lesion biopsy prior to MRI scanning. 4.Patients whose LVI status cannot be clearly determined by pathology

Design outcomes

Primary

Measure	Time frame
Area under the ROC curve;	—

Secondary

Measure	Time frame
Imaging Features;	—

Countries

China

Contacts

Public ContactJiayi Huang

Shenshan Central Hospital, Sun Yat sen Memorial Hospital of Sun Yat sen University

huangjy359@mail.sysu.edu.cn+86 189 9895 8893

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026