Ischemic cerebrovascular disease
Conditions
Interventions
FFR guided treatment group :Pd/Pa=0.7 is used for the standard of interventional treatment in FFR guided treatment group.
DSA stenosis rate guided treatment group:DSA stenosis rate ?70% is used for the standard of interventional treatment in DSA guided treatment group.
Sponsors
Beijing Haidian Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inpatients aged 18-80 years; 2. The degree of middle cerebral artery stenosis was 50%-99%; 3. There were ischemic lesions in the middle cerebral artery territory on the lesion side, which were consistent with cortical or subcortical embolism, hypoperfusion combined with microemboli clearance disorder, or carrier atherosclerotic plaque blocking the perforating branch; 4. All patients voluntarily participated in this study, and patients and their families signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Symptomatic patients with only local perforator artery infarction; 2. Non-atherosclerotic MCA stenosis (e.g., dissection, moyamoya disease, or vasculitis); 3. Patients with heart, kidney and other important organ lesions who cannot tolerate DSA examination; 4. Simultaneous intracranial or extracranial stenosis of ipsilateral internal carotid artery >50%; 5. MRS>=3, life expectancy less than 1 year; 6. Massive cerebral infarction (1/2MCA territory); 7. Patients with known intracranial tumor, infection, hydrocephalus, aneurysm or arteriovenous malformation; 8. Family members are unwilling to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRS; | — |
Countries
China
Contacts
Public ContactXiaobing Li
Beijing Haidian Hospital
Outcome results
None listed