Skip to content

Effect of G-protein-biased µ-opioid agonist (oxelidine) on gastrointestinal function in elderly patients after abdominal surgery: a randomized, multicenter controlled trial

Effect of G-protein-biased µ-opioid agonist (oxelidine) on gastrointestinal function in elderly patients after abdominal surgery: a randomized, multicenter controlled trial

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400094566
Enrollment
Unknown
Registered
2024-12-24
Start date
2024-12-24
Completion date
Unknown
Last updated
2025-01-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

POGD

Interventions

Oxeridine group:PCIA regimen was oxeridine 0.6mg/kg+ Flurbiprofen ester 100mg+ tropisetron 10mg
Sufentanil group:The PCIA regimen is sufentanil 3ug/kg + flurbiprofen cilexil 100 mg + tropisetron 10 mg

Sponsors

Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Sign the informed consent form. (2) It is planned to undergo abdominal laparoscopic surgery under general anesthesia (the surgical sites include the stomach, intestines, liver, gallbladder and appendix). (3) Be older than 60 years old. (4) Be at ASA level I - III. (5) The estimated duration of the surgery is 1 to 5 hours. (6) The patient is planned to adopt patient-controlled intravenous analgesia (PCIA) for pain relief after the operation.

Exclusion criteria

Exclusion criteria: (1) Known gastrointestinal motility disorders (2) history of abdominal surgery (3) history of coronary artery bypass grafting, active gastrointestinal bleeding, and perforation (4) severe hepatorenal dysfunction (5) Psychiatric patients (6) history of airway difficulties or delayed extubation (7) abuse of anesthesia and sedation drugs (8) history of allergic reactions to related drugs (9) emergency reoperation (10) preoperative cognitive function Impairment of energy

Design outcomes

Primary

MeasureTime frame
Patient's self-reported first exhaust time;

Countries

P.R.China

Contacts

Public ContactLi Xiang

Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

lixiang27@mail.sysu.edu.cn+86 156 0239 1780

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026